Begin with Orientation in Downtown, then follow Welcome to Manhattan to reach Zoe's briefing. From there, the campaign opens up: main assignments, the search for Jesse and optional activities can overlap. This walkthrough is an opening-route guide, with detailed solutions linked where a mission needs its own explanation.

Opening mission route

From the Oldest House to the Field Office

  1. Orientation — Downtown

    Learn the opening combat and movement systems, complete the first Fault and defeat The Artist.

  2. Welcome to Manhattan

    Reach Zoe at the Watchtower and examine the distant points of interest she identifies.

  3. Evacuation Procedures

    Follow the main assignment into the Evacuation Zone.

  4. Arish’s Briefing — Central

    Return to the Field Office briefing before the power-station assignment.

  5. Power Lines

    Reroute the first three stations, then resolve the Vanished Station.

If Orientation stops you

The first Fault provides early movement skills; it is not the same progression source as a Resonant boss. The Artist fight ends the prologue's boss sequence and gives a choice of combat ability. If you keep taking damage during its airborne phase, use the rising pavement to reach it instead of waiting below for projectiles.

Choose the next objective deliberately

After the Watchtower, inspect the points of interest so the corresponding leads enter your quest log. Following Jesse into the West Incursion Zone leads toward Shift. The Evacuation Zone Fault provides Reach. These routes unlock access that ordinary leveling alone cannot supply.

A Resonant hunt grants combat progression but also refreshes enemy encounters. If you want a quieter exploration pass, collect nearby resources and finish a local puzzle before triggering the next cycle. When a story objective becomes difficult, the first-hours checklist covers the upgrades available without simply retrying the same fight.

Detours with their own solutions

The source walkthrough was still expanding at launch. This page does not label its opening mission list as a complete list of every later quest. Story-ending details are kept on the separately marked ending page.

When a quest stops progressing

Remedy lists a missing final subwoofer interaction in The Complete Set as a known issue. That report does not provide a confirmed workaround for the speaker quest. Do not treat a missing prompt as proof that the placement solution is wrong, or delete a save to retry it. Check the official issue page for a delivered fix; a fix planned for the next update is not the same as a patch already released.

The same support page recommends reloading the last checkpoint for the named Evacuation Protocols barrier issue and the distant enemy in The End. Those workarounds apply to those specific symptoms, not automatically to every stuck quest. For the six experiment sites, use the complete Unsupervised Science route.